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 具修飾側鏈之RNA病毒衍生胜肽及其用途
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刊登日期：2014/05/21 |
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| ‧ 專利名稱 |
具修飾側鏈之RNA病毒衍生胜肽及其用途 |
| ‧ 專利證書號 |
I429747
I429747
US 8,524,659
US8524659B2
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| ‧ 專利權人 |
國立臺灣大學 |
‧ 專利國家
(申請日) |
中華民國 (2011/11/02)
美國 (2012/04/05)
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| ‧ 發明人/PI |
陳平,吳政勳 ,翁明暉 ,黃立民 ,
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| ‧ 單位 |
化學系
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| ‧ 簡歷/Experience |
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| 技術摘要 / Our Technology： |
本發明提供一種具修飾側鏈之RNA病毒衍生胜肽，其能藉由調整側鏈長短或電性而修飾胜肽側鏈，而使此胜肽對RNA病毒具高親和力並有優異的細胞穿越能力。本發明亦提供一種以抑制RNA病毒之醫藥組合物，利用前述RNA病毒衍生胜肽的高親和力，抑制病毒自我複製，以有效治療RNA病毒相關疾病。本發明另提供一種藥物傳輸之載體，利用前述RNA病毒衍生胜肽的細胞穿越能力，有效地攜帶藥物至欲治療標的，以提高藥物的傳輸及治療效率。
The present invention provides a RNA virus-derived peptides with modified side chains, wherein the side chains of the RNA virus-derived peptide are modified by altering the side-chain length or charges thereof such that the RNA virus-derived peptide has a high binding affinity for viral RNA and an high cellular uptake capability. The present invention also provides a composition for inhibiting RNA virus wherein the RNA virus-derived peptide can effectively inhibit viral self-replication and treat related diseases by its high affinity for viral RNA. A drug delivery carrier is also provided, wherein the RNA virus-derived peptides can carry desired drugs to the intracellular target due to its cellular uptake capability and thereby enhances the drug-delivery and treating efficiency.
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| 專利簡述 / Intellectual Properties： |
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聯繫方式 / Contact： |
| 臺大產學合作總中心 / Center of Industry-Academia Collaboration, NTU |
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| Email：ordiac@ntu.edu.tw |
電話/Tel：02-3366-9945 |
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