牛樟芝之抗癌活性物質、製備方法及其用途(An Anti-Cancer Active Substance from Antrodia Camphorata, Method for Preparing the same and Use Thereof)
  ‧ 專利名稱 牛樟芝之抗癌活性物質、製備方法及其用途(An Anti-Cancer Active Substance from Antrodia Camphorata, Method for Preparing the same and Use Thereof)
  ‧ 專利證書號 1415669
5752925
  ‧ 專利權人 國立臺灣大學
  ‧ 專利國家
    (申請日)
中國 (2010/09/30)
歐洲 (2010/11/22)
美國 (2010/11/24)
日本 (2010/11/25)
馬來西亞 (2010/11/25)
  ‧ 發明人 蔣丙煌, 林育蔚,
 
技術摘要:
An anti-cancer active substance from Antrodia Camphorata, produced from mycelium of Antrodia Camphorata by following steps: (1) culturing mycelium of Antrodia Camphorata by liquid fermentation; (2) extracting the thus-obtained mycelium with ethanol and concentrating the extracted solution to obtain an ethanol extract; (3) dissolving the ethanol extract in water, and extracting with equal volume of ethyl acetate to obtain ethyl acetate extract; (4) purifying the ethyl acetate extract by silica gel column chromatography using hexane/ethyl acetate gradient as the mobile phase to obtain an eluate fraction g; and (5) purifying the eluate fraction g by silica gel column chromatography using hexane/ethyl acetate gradient as the mobile phase to obtain a specific eluate fraction which could be purified further to obtain the anti-cancer active substance from Antrodia Camphorata.



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