葫蘆烷型三萜類化合物、醫藥組成物、用途及其萃取方法
  ‧ 專利名稱 葫蘆烷型三萜類化合物、醫藥組成物、用途及其萃取方法
  ‧ 專利證書號 I395587
US 8,669,244 B2
  ‧ 專利權人 國立臺灣大學
  ‧ 專利國家
    (申請日)
中華民國 (2011/04/01)
美國 (2011/06/30)
  ‧ 發明人 黃青真 , 郭悅雄, 徐瑨,
 
技術摘要:
本發明揭露一種葫蘆烷型三萜類化合物、醫藥組成物、用途及其萃取方法,該化合物係如式(I)所示:
(I)
其中C5和C10之間形成單鍵或雙鍵,C8和C9之間形成單鍵或雙鍵;其中C5和C10之間形成單鍵時,R1係為氧;其中C8和C9之間形成單鍵時,R2係為羰基、甲羥基、甲醛基或甲基二甲氧基;其中R1為氧且R2為羰基或甲羥基時,R1之氧與R2的C19形成單鍵,R1 R2=戊內酯或半縮醛環。

Disclosed is a cucurbitane-triterpenoid compound for activating estrogen receptor activity, and a pharmaceutical composition, use and preparation method thereof. The cucurbitane-triterpenoid compound is presented as formula (I):
Figure US20120252772A1-20121004-C00001
wherein a single bond or a double bond is formed between C5 and C10, and a single bond or a double bond is fromed between C8 and C9; when a single bond is formed between C5 and C10, the R1 is oxygen; while a single bond is formed between C8 and C9, R2 is carbonyl group (—C═O), methyl hydroxyl group (—CH(OH)), methyl ketone or methyl dimethoxy group (—CH(OCH3)2); and wherein while R1 is oxygen (—O—) and R2 is carbonyl group (—C═O) or methyl hydroxyl group (—CH(OH)), a single bond is formed between R1 (—O—) and C19 of R2 such that R1 and R2 are formed tetrahydro-2H-pyran-2-one or hemiacetal ring.



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