正篩選免疫磁珠標定微粒之分離方法
  ‧ 專利名稱 正篩選免疫磁珠標定微粒之分離方法
  ‧ 專利證書號 I381163
US 8,535,541
  ‧ 專利權人 國立臺灣大學
  ‧ 專利國家
    (申請日)
中華民國 (2009/09/10)
美國 (2010/08/24)
  ‧ 發明人 胡文聰, 潘宇誠, 陳畊兆, 陳貞伶,
 
技術摘要:
該方法係將流體樣本中之標的微粒以免疫磁珠標定後,將流體樣本注入內貯置槽,並施加一磁性吸附力及一驅動力,該施加之驅動力將未標定有免疫磁珠之非標的微粒隨流體樣本經由微流道導流,分離至外貯置槽,而該施加之磁性吸附力,則將標定有免疫磁珠之標的微粒吸附留置於內貯置槽中。其中,驅動力為離心力、壓力及界面力之一。
Disclosed is a method for separating immunomagnetic bead labeled particulates. A carrier board is formed with at least one flow channel structure, which includes an inner reservoir, an outer reservoir, and at least one micro flow channel in communication with the inner reservoir and the outer reservoir. The method includes labeling target particulates with immunomagnetic bead, introducing a sample fluid into the inner reservoir, and applying a magnetic force and a driving force, wherein the driving force drives the particulates not labeled with immunomagnetic bead to flow through the micro flow channel to the outer reservoir, while the magnetic force attracts the particulates labeled with the immunomagnetic bead to retain in the inner reservoir. The driving force may be centrifugal force, pressure, or surface tension.




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