|
 人類B型肝炎病毒持續表現之小鼠模式(RECOMBINANT PLASMID AND METHOD FOR EXPRESSING HEPATITIS B VIRAL ANTIGENS AND VIRIONS IN VIVO)
|
刊登日期：2014/05/21 |
|
|
|
|
|
| ‧ 專利名稱 |
人類B型肝炎病毒持續表現之小鼠模式(RECOMBINANT PLASMID AND METHOD FOR EXPRESSING HEPATITIS B VIRAL ANTIGENS AND VIRIONS IN VIVO) |
| ‧ 專利證書號 |
US 7,452,696 B2
|
| ‧ 專利權人 |
國立臺灣大學 |
‧ 專利國家
(申請日) |
美國 (2006/10/27)
|
|
|
| |
| ‧ 發明人/PI |
陳培哲,黃麗蓉,吳慧琳,陳定信,
|
| ‧ 單位 |
臨床醫學研究所
|
| ‧ 簡歷/Experience |
|
|
| 技術摘要 / Our Technology： |
Disclosed is a recombinant plasmid for expressing hepatitis B viral antigens in vivo, comprising an adeno-associated virus (AVV) vector and a replication-competent hepatitis B virus genome fragment. Mice hydrodynamically injected with the recombinant plasmid of the present invention show persistent expression of hepatitis B viral antigens for more than 6 months in the hepatocytes, thus a immuno-competent mouse model for persistent expression of hepatitis B antigens and also for human chronic hepatitis B virus infection is established, which can be applied in evaluation and elucidation of mechanism of chronic hepatitis and anti-viral drug discovery research.
|
| 專利簡述 / Intellectual Properties： |
|
| |
聯繫方式 / Contact： |
| 臺大產學合作總中心 / Center of Industry-Academia Collaboration, NTU |
|
| Email：ordiac@ntu.edu.tw |
電話/Tel：02-3366-9945 |
|
|
| |
|
| |
 |
專利行銷平台