人類B型肝炎病毒持續表現之小鼠模式(RECOMBINANT PLASMID AND METHOD FOR EXPRESSING HEPATITIS B VIRAL ANTIGENS AND VIRIONS IN VIVO)
刊登日期:2014/05/21
  ‧ 專利名稱 人類B型肝炎病毒持續表現之小鼠模式(RECOMBINANT PLASMID AND METHOD FOR EXPRESSING HEPATITIS B VIRAL ANTIGENS AND VIRIONS IN VIVO)
  ‧ 專利證書號 US 7,452,696 B2
  ‧ 專利權人 國立臺灣大學
  ‧ 專利國家
    (申請日)
美國 (2006/10/27)
 
  ‧ 發明人/PI 陳培哲,黃麗蓉,吳慧琳,陳定信,
  ‧ 單位 臨床醫學研究所
  ‧ 簡歷/Experience
技術摘要 / Our Technology:
Disclosed is a recombinant plasmid for expressing hepatitis B viral antigens in vivo, comprising an adeno-associated virus (AVV) vector and a replication-competent hepatitis B virus genome fragment. Mice hydrodynamically injected with the recombinant plasmid of the present invention show persistent expression of hepatitis B viral antigens for more than 6 months in the hepatocytes, thus a immuno-competent mouse model for persistent expression of hepatitis B antigens and also for human chronic hepatitis B virus infection is established, which can be applied in evaluation and elucidation of mechanism of chronic hepatitis and anti-viral drug discovery research.




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