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 Novel Hydrophilic Derivatives Of 2-Aryl-4-Quinolones As Anticancer Agents
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刊登日期：2014/05/21 |
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| ‧ 專利名稱 |
Novel Hydrophilic Derivatives Of 2-Aryl-4-Quinolones As Anticancer Agents |
| ‧ 專利證書號 |
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| ‧ 專利權人 |
中國醫藥大學 |
‧ 專利國家
(申請日) |
PCT (2007/12/07)
中國 (2007/12/07)
中華民國 (2007/12/07)
日本 (2007/12/07)
加拿大 (2007/12/07)
印度 (2007/12/07)
沙烏地阿拉伯 (2007/12/07)
俄羅斯 (2007/12/07)
美國 (2007/12/07)
紐西蘭 (2007/12/07)
歐洲 (2007/12/07)
澳洲 (2007/12/07)
韓國 (2007/12/07)
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| ‧ 發明人/PI |
鄧哲明,潘秀玲,
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| ‧ 單位 |
藥理學科暨研究所
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| ‧ 簡歷/Experience |
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| 技術摘要 / Our Technology： |
2-aryl-4-quinolones are converted into phosphates by reacting with tetrabenzyl pyrophosphate to form dibenzyl phosphates thereof, which are then subject to hydrogenation to replace dibenzyl groups with H, followed by reacting with Amberlite IR-120(Na+ form) to form disodium salts. The results of preliminary screening revealed that these phosphates showed significant anti-cancer activity. A novel intermediate, 2-selenophene 4-quinolone and ?/, ?/-dialkylaminoalkyl derivatives of 2-phenyl-4-quinolones are also synthesized. These novel intermediates exhibited significant anticancer activities.
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| 專利簡述 / Intellectual Properties： |
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聯繫方式 / Contact： |
| 臺大產學合作總中心 / Center of Industry-Academia Collaboration, NTU |
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| Email：ordiac@ntu.edu.tw |
電話/Tel：02-3366-9945 |
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