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 醫用超順磁奈米粒子及其製造方法 |
刊登日期：2014/05/21 |
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| ‧ 專利名稱 |
醫用超順磁奈米粒子及其製造方法 |
| ‧ 專利證書號 |
I379689
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| ‧ 專利權人 |
國立臺灣大學 |
‧ 專利國家
(申請日) |
中華民國 (2009/05/27)
美國 (2009/12/03)
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| ‧ 發明人 |
吳錫芩 , 林峰輝, 王子威, |
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| 技術摘要： |
一種醫用超順磁奈米粒子及其製造方法，其步驟首先提供含有磷酸鈣鹽類顆粒的懸浮液，以及提供含有磁性金屬離子的金屬離子溶液。接著，將懸浮液與金屬離子溶液相混合，並將此混合液以鹼性溶液滴定至酸鹼值呈鹼性。接著令磁性金屬離子磊晶成長於磷酸鈣鹽類顆粒的表面，然後從混合液中分離並收集具有磁性金屬晶粒的磷酸鈣鹽類顆粒。這些具有磁性金屬晶粒的磷酸鈣鹽類顆粒帶有超順磁的特性，可做為生物醫學領域之應用。
The successful transfer of therapeutic agents such as genetic materials (e.g. nucleic acid) or drug into living cells is the most important issue depending on the development of the delivery carrier. A method for manufacturing superparamagnetic nanoparticles in medical therapeutics is described to develop nano-sized calcium phosphate (CaP) mineral was rendered magnetic as delivery vehicle. The CaP-based magnetized nanoparticles (NPs) were possessed superparamagnetic property by hetero-epitaxial growth of magnetite on the CaP crystallites and also showed no harm to the cultured cells and elicited no cytotoxicity. The magnetized CaP was demonstrated to have good plasmid DNA binding affinity or drug carrying capacity. It significantly increased the expression of gene transfection and efficiency in delivery to mesenchymal stem cells (MSCs) under exogenous magnetic field. According to the above facts, this newly-synthesized magnetized CaP NPs has great potential as a novel non-viral targeted delivery vehicle to be applied for medical applications.
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聯繫方式 |
| 聯絡人：
研發處產學合作總中心 |
電話：
(02)3366-9949 |
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| 地 址：
10617臺北市大安區羅斯福路四段1號 禮賢樓六樓608室 |
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