預防或治療慢性心臟疾病之藥物及醫藥組成物
  ‧ 專利名稱
  ‧ 專利證書號
  ‧ 專利權人 台大(50%)、中國醫藥大學(50%)
  ‧ 專利國家
    (申請日)
中華民國 (2011/05/03)
美國 (2012/03/27)
  ‧ 發明人 蘇銘嘉 , 郭悅雄,
 
技術摘要:
本發明係揭露一種以鄰苯二酚(catechol)為架構之衍生化合物,以及其醫學上可接受的鹽類或溶劑化物。該等化合物用於慢性心衰竭之長期治療。其中以鄰苯二酚為架構的衍生化合物具有下列結構式(I)。

The present invention provides a pharmaceutical composition for preventing or treating a chronic heart disease, comprising a compound of a formula (I):
Figure US20120283200A1-20121108-C00001
wherein:
R1 is one independently selected from a group consisting of a hydrogen, a methyl and an ethyl;
R2 is one of a hydrogen and a methyl; and
R3 is one selected from a group consisting of a hydrogen, (CH2)nAr and (CH2)nArR′R″, wherein n is one of 1 and 2, R′ and R″ is located at C-3 and C-4 positions, respectively, R′ is a hydrogen and R″ is one of a hydroxy, a fluorine, a bromine and a OMe, or R′+R″=—OCH2O—; or
R2+R3 is one of
Figure US20120283200A1-20121108-C00002
wherein n is one of 4 and 5.



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