碟片型免疫磁珠標定細胞之分離及檢測平台
  ‧ 專利名稱 碟片型免疫磁珠標定細胞之分離及檢測平台
  ‧ 專利證書號 I369494
US 8,039,249
  ‧ 專利權人 國立臺灣大學
  ‧ 專利國家
    (申請日)
中華民國 (2008/12/12)
美國 (2009/03/25)
  ‧ 發明人 胡文聰, 陳貞伶, 陳畊兆, 潘宇誠,
 
技術摘要:
一種碟片型免疫磁珠標定細胞之分離及檢測平台,係於一碟型載板上形成有至少一組流道結構,每一組流道結構包括有一用以貯置流體樣本之內貯置槽、一外貯置槽及複數條連通於內貯置槽及外貯置槽之間之微流道,以當碟型載板受驅動旋轉時,流體樣本中標定有免疫磁珠之細胞受一設置在碟型載板之上方並鄰近於內貯置槽之磁吸單元所吸引,留存在內貯置槽中,而未標定有免疫磁珠之細胞,則藉由碟型載板旋轉所產生之離心力,隨流體樣本自內貯置槽經由微流道收集至外貯置槽。

Disclosed is a disk based platform for separating and detecting cells that are labeled with immunomagnetic beads. A disk-like carrier board forms therein at least one flow channel structure, which includes an inner reservoir for receiving a sample fluid, an outer reservoir, and a plurality of micro flow channels arranged between and in fluid communication with the inner and outer reservoirs. When the disk-like carrier board spins, cells labeled with immunomagnetic beads are attracted by a magnetic attraction unit that is arranged above the disk-like carrier board and adjacent to the inner reservoir to thereby remain in the inner reservoir, and cells that are not so labeled are acted upon by a centrifugal force induced by the spinning of the disk-like carrier board to flow with the sample fluid from the inner reservoir through the micro flow channels into the outer reservoir.



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