具修飾側鏈之RNA病毒衍生胜肽及其用途
  ‧ 專利名稱 具修飾側鏈之RNA病毒衍生胜肽及其用途(RNA Virus-Derived Peptides With Modified Side Chains)
  ‧ 專利證書號 I429747
US 8,524,659
  ‧ 專利權人 國立臺灣大學
  ‧ 專利國家
    (申請日)
中華民國 (2011/11/02)
美國 (2012/04/05)
  ‧ 發明人 陳平, 吳政勳 , 翁明暉 , 黃立民 ,
 
技術摘要:
本發明提供一種具修飾側鏈之RNA病毒衍生胜肽,其能藉由調整側鏈長短或電性而修飾胜肽側鏈,而使此胜肽對RNA病毒具高親和力並有優異的細胞穿越能力。本發明亦提供一種以抑制RNA病毒之醫藥組合物,利用前述RNA病毒衍生胜肽的高親和力,抑制病毒自我複製,以有效治療RNA病毒相關疾病。本發明另提供一種藥物傳輸之載體,利用前述RNA病毒衍生胜肽的細胞穿越能力,有效地攜帶藥物至欲治療標的,以提高藥物的傳輸及治療效率。

The present invention provides a RNA virus-derived peptides with modified side chains, wherein the side chains of the RNA virus-derived peptide are modified by altering the side-chain length or charges thereof such that the RNA virus-derived peptide has a high binding affinity for viral RNA and an high cellular uptake capability. The present invention also provides a composition for inhibiting RNA virus wherein the RNA virus-derived peptide can effectively inhibit viral self-replication and treat related diseases by its high affinity for viral RNA. A drug delivery carrier is also provided, wherein the RNA virus-derived peptides can carry desired drugs to the intracellular target due to its cellular uptake capability and thereby enhances the drug-delivery and treating efficiency.



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