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 得到一影像生物指標的方法、病況預測方法、病況預測裝置及電腦程式產品
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刊登日期：2014/05/21 |
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| ‧ 專利名稱 |
得到一影像生物指標的方法、病況預測方法、病況預測裝置及電腦程式產品(METHOD AND APPARATUS FOR ACQUIRING AN IMAGE BIOMARKER AND PROGNOSING A BLOOD RELATED DISEASE) |
| ‧ 專利證書號 |
I 387445
US8,855,741 B2
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| ‧ 專利權人 |
國立臺灣大學 |
‧ 專利國家
(申請日) |
中華民國 (2009/09/17)
美國 (2010/02/23)
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| ‧ 發明人/PI |
施庭芳 ,施國琛 ,
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| ‧ 單位 |
醫學系 放射線科
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| ‧ 簡歷/Experience |
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| 技術摘要 / Our Technology： |
一種病況預測方法，包含以下步驟：(a)利用磁振掃描儀來掃描有注射顯影劑之病患，以得到多張連續影像；(b)將步驟(a)所得到的影像處理成一時間-訊號強度曲線；(c)得到該時間-訊號強度曲線的一組物理量，且該組物理量至少包含二種物理量；(d)將該組物理量權重後相加，以得到一風險因子；(e)基於風險因子的值判斷病況；當值愈高，則判斷病況愈嚴重且疾病預後更差。因本發明得到的風險因子結合了多種物理量的資訊，故帶有更全面的訊息，而使預測的可信度增加，故為一種有效的生物指標，且此方法具有非侵入性而且可以重覆量測的特性。
A method of acquiring an image biomarker suitable for prognosis of a blood-related disease, such as acute myeloid leukemia, includes the steps of: (a) acquiring physical parameter sets, each including at least two physical parameters, respectively from time-signal intensity curves, the time-signal intensity curves being respectively obtained from magnetic resonance image sets of different subjects that are diagnosed as having the blood-related disease, each of the image sets being acquired through MRI scanning using one of first and second configuration parameter sets; (b) analyzing the physical parameter sets thus acquired with reference to prognoses of the different subjects so as to obtain weight values corresponding to the physical parameters; and (c) establishing a risk score function that is a sum of products of each of the physical parameters and the corresponding weight value, wherein a risk score obtained using the risk score function serves as the image biomarker suitable for prognosis of the blood-related disease.
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| 專利簡述 / Intellectual Properties： |
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聯繫方式 / Contact： |
| 臺大產學合作總中心 / Center of Industry-Academia Collaboration, NTU |
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| Email：ordiac@ntu.edu.tw |
電話/Tel：02-3366-9945 |
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