‧ 專利名稱	以斑馬魚模組進行藥物篩選之方法及篩選所得藥物
‧ 專利證書號	特許6300856 10201701145U
‧ 專利權人	國立臺灣大學
‧ 專利國家     (申請日)	日本 (2016/04/07) 新加坡 (2016/04/07) 韓國 (2017/07/14)
‧ 單位	醫學系 眼科
‧ 發明人 / PI	王一中,江亭萱,林奕岑,何威廷,
‧ 簡歷 / Experience

The invention relates to a platform of using zebrafish in screening candidates for treating and/or preventing myopia and keratoconus disease. The invention is mainly based on that lumican, one of several SLRPs, plays an important role in the regulation of fibrillogenesis or the genes affecting the size of eyeballs in zebrafish, in addition to playing an important role in clinical myopia. Therefore, the invention uses the established zebrafish model to further identify the drugs affecting the expression of lumican and collagen fibrillogenesis, and/or the regulation of eyeball size. These drugs are potential candidates for treating myopia and/or keratoconus disease.

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