得到一影像生物指標的方法、病況預測方法、病況預測裝置及電腦程式產品
刊登日期:2014/05/21
  ‧ 專利名稱 得到一影像生物指標的方法、病況預測方法、病況預測裝置及電腦程式產品(METHOD AND APPARATUS FOR ACQUIRING AN IMAGE BIOMARKER AND PROGNOSING A BLOOD RELATED DISEASE)
  ‧ 專利證書號 I 387445
US8,855,741 B2
  ‧ 專利權人 國立臺灣大學
  ‧ 專利國家
    (申請日)
中華民國 (2009/09/17)
美國 (2010/02/23)
 
  ‧ 發明人/PI 施庭芳 ,施國琛 ,
  ‧ 單位 醫學系 放射線科
  ‧ 簡歷/Experience
技術摘要 / Our Technology:
一種病況預測方法,包含以下步驟:(a)利用磁振掃描儀來掃描有注射顯影劑之病患,以得到多張連續影像;(b)將步驟(a)所得到的影像處理成一時間-訊號強度曲線;(c)得到該時間-訊號強度曲線的一組物理量,且該組物理量至少包含二種物理量;(d)將該組物理量權重後相加,以得到一風險因子;(e)基於風險因子的值判斷病況;當值愈高,則判斷病況愈嚴重且疾病預後更差。因本發明得到的風險因子結合了多種物理量的資訊,故帶有更全面的訊息,而使預測的可信度增加,故為一種有效的生物指標,且此方法具有非侵入性而且可以重覆量測的特性。

A method of acquiring an image biomarker suitable for prognosis of a blood-related disease, such as acute myeloid leukemia, includes the steps of: (a) acquiring physical parameter sets, each including at least two physical parameters, respectively from time-signal intensity curves, the time-signal intensity curves being respectively obtained from magnetic resonance image sets of different subjects that are diagnosed as having the blood-related disease, each of the image sets being acquired through MRI scanning using one of first and second configuration parameter sets; (b) analyzing the physical parameter sets thus acquired with reference to prognoses of the different subjects so as to obtain weight values corresponding to the physical parameters; and (c) establishing a risk score function that is a sum of products of each of the physical parameters and the corresponding weight value, wherein a risk score obtained using the risk score function serves as the image biomarker suitable for prognosis of the blood-related disease.





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