剔除轉錄活化因子之基因老鼠及其使用(NRIP KNOCKOUT MICE AND USES THEREOF)
  ‧ 專利名稱 剔除轉錄活化因子之基因老鼠及其使用(NRIP KNOCKOUT MICE AND USES THEREOF)
  ‧ 專利證書號 US 8,729,335 B2
  ‧ 專利權人 國立臺灣大學
  ‧ 專利國家
    (申請日)
美國 (2012/11/29)
 
  ‧ 發明人/PI 陳小梨,陳信雄,林冠良,嚴婉倫,
  ‧ 單位 微生物學科暨研究所
  ‧ 簡歷/Experience
技術摘要 / Our Technology:
本發明係關於一種用於調控慢速肌凝蛋白表現量之醫藥組合物,包含一有效量藥物可接受性之核受體交互作用蛋白調控劑或其醫藥上可接受之鹽類及一種醫藥上可接受之載劑。

The present invention provides a method for modulating an expression level of a gene encoding slow myosin in a subject in need thereof, comprising administering to said subject a pharmaceutically effective amount of a nuclear receptor interaction protein (NRIP) and a pharmaceutically acceptable carrier. The present invention also provides a method for modulating an expression level of a gene encoding slow myosin in a subject in need thereof, comprising administering to said subject a pharmaceutically effective amount of an expression vector comprising a gene encoding a nuclear receptor interaction protein (NRIP) and a pharmaceutically acceptable carrier. In a preferred embodiment, the expression vector is an adenoviral vector.





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