一種拮抗介白素-6的寡胜肽(Oligopeptide antagonist of interleukin-6)
刊登日期:2014/05/21
  ‧ 專利名稱 一種拮抗介白素-6的寡胜肽(Oligopeptide antagonist of interleukin-6)
  ‧ 專利證書號 US 7,202,218 B2
  ‧ 專利權人 國立臺灣大學
  ‧ 專利國家
    (申請日)
美國 (2005/08/03)
 
  ‧ 發明人/PI 魏凌鴻,蘇振良,郭明良,
  ‧ 單位 腫瘤醫學研究所
  ‧ 簡歷/Experience
技術摘要 / Our Technology:
The present invention provides an antagonist peptide of interleukin-6 (IL-6), wherein the peptide comprises a amino acid sequence which is selected from the group consisting of SEQ ID NO: 5, SEQ ID NO: 6 and SEQ ID NO: 7. The peptide of the invention is able to specifically bind IL-6R and compete for the binding of IL-6 to IL-6R, to block IL-6-induced signal transduction and therefore effectively inhibits IL-6-mediated antiapotopsis and angiogenesis, and further inhibits IL-6-mediated tumor growth.



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